Which is effective and safe for persistent pulmonary hypertension after pulmonary endarterectomy, NO or Flolan?

UMIN ID: UMIN000009460

Registered date:01/01/2013

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: persistent pulmonary hypertension after pulmonary endarterectomy
• Date of first enrollment: 2012/12/01
• Target sample size: 16
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

NO inhalation therapy will begin, if the patient develops pulmonary hypertension (mean pulmonary artery pressure above 25 mmHg) after separation from cardiopulmonary bypass. NO therpy will stop, if pulmonary hypertension relieves or the patient is extubated.
Flolan inhalation therapy will begin, if the patient develops pulmonary hypertension (mean pulmonary artery pressure above 25 mmHg) after separation from cardiopulmonary bypass. Flolan therpy will stop, if pulmonary hypertension relieves or the patient is extubated.

Outcome(s)

• Primary Outcome: effectiveness of lowering pulmonary artery pressure

Key inclusion & exclusion criteria

• Age minimum: Not applicable
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: patients with bleeding complication will be excluded.

Related Information

• Primary Sponsor: Dept. of Cardiovascular Surgery, Chiba University Hospital
• Source(s) of Monetary Support: none