Vildagliptin versus Standard Therapy on Coronary flow reserve in Type2 Diabetes Mellitus-Juntendo

UMIN ID: UMIN000008358

Registered date:10/07/2012

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: Type 2 Diabetes Mellitus
• Date of first enrollment: 2012/07/01
• Target sample size: 40
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

The therapy using Vildagliptin on type2 diabetes mellitus
Standard therapy on type2 diabetes mellitus

Outcome(s)

• Primary Outcome: The change of coronary flow reserve assessed by echocardiography

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: Exclusion criteria 1) Patients with coronary stenosis at left anterior descending artery 2) Allergy for dipeptidyl-peptidase4 inhibitor and sulfonylureas 3) Ongoing treatment with a DPP-4 inhibitor, GLP-1 analog and insulin 4) Patients with diabetic ketoacidosis or diabetic coma or type 1 diabetes 5) Patients who underwent 2 or over stents implantation for left anterior descending artery 6) Severe liver dysfunction 7) Patients with moderate or severe renal disorder (creatinine level: 1.5 mg/dL [men] or 1.3 mg/dL [women]). 8) Old anterior wall myocardial infarction 9) Pregnant or nursing woman 10)Other patients judged as being inappropriate for the subjects of the study by investigators.

Related Information

• Primary Sponsor: Juntendo University School of Medicine
• Source(s) of Monetary Support: Juntendo University School of Medicine