NIPH Clinical Trials Search

UMIN ID: UMIN000005554

Registered date:11/05/2011

Analysis of the Physiological Mechanism of Aromatherapy by Biological Sensing Technology

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedyoung healthy adults
Date of first enrollment2011/05/01
Target sample size50
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)Control and treatment groups are set up. Fundamental researches of the physiological mechanism of the aromatherapy by various stress tasks. 1. pain stress task 2. Mental stress task 3. exercise task Short-term test: 1. Baseline, stress, essential oils massage (60 minutes), stress. 2. Baseline, stress, a rest in the relaxation room (60 minutes), stress. Long-term test: The subjects whose stress does not improve by the short-term testing are selected, and aroma massage is given to them once every two weeks for three months.


Primary Outcome1. Central nervous system activity Electroencephalograph (EEG), cerebral blood flow 2. Peripheral physiological response 1) Physiological data: Electrocardiogram, Volume pulse wave, Core body temperature, Respiratory rate, Blood pressure, Skin electrical conducitivity 2) Biochemical data (blood tests): cortisol, noradrenaline, IgA, IFN, IL-1, IL-6, WBC count, neutrophil count, lymphocyte count, CD4/8, NK cell activity 3) Basal metabolic rate 3. Psychological response POMS (profile of mood state) VAS(Visual analogue scale) Before and after three months intervention.
Secondary OutcomeStress Control

Key inclusion & exclusion criteria

Age minimum18years-old
Age maximum40years-old
GenderMale and Female
Include criteria
Exclude criteriaInappropriate subjects for this study judged by the diagnosticians. 1. Those who have severe heart, liver or kidney disease. 2. Those who have a tendency to develop allergy by plants and perfume. 3. Those who have tested positive to an allergy test. 4. Those who received full body massage with aroma oil within one month. 5. Those who cannot agree to participate in this trial

Related Information


public contact
Name Tomomi Bohgaki
Address 3-15-1,Nakatomigaoka, Nara-shi, Nara. Japan
Telephone 0742-95-9800
Affiliation Naragakuen University Faculty of Health Sciences
scientific contact
Name Makoto Usami
Address 7-10-2, Tomogaoka, Suma-ku, Kobe City, Hyogo, Japan Japan
Telephone 078-792-2555
Affiliation Kobe University Graduate School of Heath Sciences Department of Biophysics Division of Nutrition and Metabolism