NIPH Clinical Trials Search

UMIN ID: UMIN000002292

Registered date:10/08/2009

Substudy of lipid lowering trial on prevention of atherosclerosis in 75 or older on cholesterol absorption and synthesis

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedHyper-LDL-cholesterolemia
Date of first enrollment2009/08/01
Target sample size1000
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)ezetimibe and diet diet


Primary Outcome0 to 24weeks (1)changes in cholesterol absorption and synthesis (2)changes in inflammation markers (3)changes in lipoproteins(RLPcholesterol, small dense LDL etc), oxydised phospholipid, oxdised cholesterol) (4)NT-proBNP
Secondary Outcomerelation to composite cardiovascular events (same as EWTOPIA75)

Key inclusion & exclusion criteria

Age minimum75years-old
Age maximumNot applicable
GenderMale and Female
Include criteria
Exclude criteriasame as EWTOPIA75

Related Information


public contact
Name Jun Sasaki, MD.PhD
Address 1-3-1 Nagahama Chuoo-ku, Fukuoka, Japan Japan
Telephone 092-711-1126
Affiliation EWTO75-Kyushu group EWTOPIA-Kyushu group office
scientific contact
Name Jun Sasaki, MD,PhD
Address 1-3-1 Nagahama Chuoku, Fukuoka, Japan Japan
Telephone 092-711-1126
Affiliation International University of Health and Welfare Pharmaceutical Medicine