NIPH Clinical Trials Search

UMIN ID: UMIN000002269

Registered date:01/08/2009

Comparative Study of Usefulness of TAZ/PIPC and MEPM in Healthcare Associated Pneumonia (HCAP): Survey on the Actual Condition of Healthcare Associated Pneumonia (HCAP) in Japan

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedHealthcare associated pneumonia (HCAP) with a pneumonia severity index (PSI) score in risk class III or IV
Date of first enrollment2009/08/01
Target sample size100
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)Administration of antibiotic (TAZ/PIPC) Administration of antibiotic (MEPM)


Primary OutcomeJudgment of cure A case judged as effective in the evaluation of clinical efficacy at the completion of administration and with no recurrence/flare-up seven days after completion of administration is judged as cured.
Secondary OutcomeJudgment of clinical efficacy A case in which the symptoms/findings of pneumonia disappear or are improved and shadows in the lungs or inflammatory findings disappear or are improved is judged as effective.

Key inclusion & exclusion criteria

Age minimumNot applicable
Age maximumNot applicable
GenderMale and Female
Include criteria
Exclude criteria*Patients with bronchial obstruction or the history of obstructive pneumonia. The patients with COPD, however, are not excluded. *Patients who can not tolerate the administration of selected drug three times a day. *Patients placed on chronic maintenance dialysis *Patients with serious hepatic dysfunction and renal dysfunction(CCr 30 ml/min or under ; -See the separate list of Scr.) *Patients who have difficulty in judgment of the efficacy of selected drug (including patients suffering from cancer or other underlying diseases which prevent the evaluation). *Patients infected probably with MRSA *Patients who are given corticosteroid (prednisolone more than 10 mg/day) *Patients with the history of hypersensitivity to the ingredients of selected drug, penicillin antimicrobials or carbapenem antimicrobials *Pregnant or breastfeeding patients, or patients who have the possibility of being pregnant *Patients with infectious mononucleosis *Patients who were judged as ineligible by their treating physicians

Related Information


public contact
Name Yoshihiro Yamamoto
Address 1-7-1, Sakamoto, Nagasaki city, Nagasaki prefecture. Japan
Telephone 095-819-7273
Affiliation Nagasaki University Hospital Second Department of Internal Medicine
scientific contact
Name Shigeru Kohno
Address 1-7-1, Sakamoto, Nagasaki city, Nagasaki prefecture. Japan
Affiliation Nagasaki University Hospital Director