UMIN ID: UMIN000002221
Registered date:01/08/2009
The screening method of reduced-function CYP2C19 polymorphisms in Japanese male
Basic Information
Recruitment status | Complete: follow-up complete |
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Health condition(s) or Problem(s) studied | clopidgrel resistance |
Date of first enrollment | 2009/08/01 |
Target sample size | 30 |
Countries of recruitment | Japan |
Study type | Interventional |
Intervention(s) | Breath test after taking 13C-pantoprazole 100mg |
Outcome(s)
Primary Outcome | Comparison the inhibition of platelet aggregation of clopidgrel between CYP2C19 wild type and reduced function polymorphisms judged by 13CO2 breath test. |
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Secondary Outcome | Comparison the activity of CYP2C19 judged by 13CO2 breath test between the CYP2C19 wild type and r polymorphisms determined by gene analysis. |
Key inclusion & exclusion criteria
Age minimum | 20years-old |
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Age maximum | Not applicable |
Gender | Male |
Include criteria | |
Exclude criteria | The history of allergy to proton pump inhibitor Liver dysfunction (AST>100IU/L ALT>100IU/L) Granulocytopenia |
Related Information
Primary Sponsor | Department of Cardiovascular Medicine, Kyoto University Hospital |
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Secondary Sponsor | NOne |
Source(s) of Monetary Support | None |
Secondary ID(s) |
Contact
public contact | |
Name | Junichi Tazaki |
Address | 54 Kawaramachi Syogoin Sakyo- kukyoto-city, Japan 606-0916 Japan |
Telephone | 075-751-4255 |
jun1@kuhp.kyoto-u.ac.jp | |
Affiliation | Kyoto university hospital The department of cardiovascular medicine |
scientific contact | |
Name | Hisanori Horiuchi |
Address | 54 Kawaramachi Syogoin Sakyo- kukyoto-city, Japan 606-0916 Japan |
Telephone | 075-751-4255 |
Affiliation | Kyoto university hospital The department of cardiovascular medicine |