NIPH Clinical Trials Search

UMIN ID: UMIN000002112

Registered date:01/07/2009

Healing Effect of Gastric mucosal Lesion of patient with Osteoarthritis or Rheumatism by Cox2-Inhibitor and Anti ulcer agent(Rebamipide) combination therapy.

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedrheumatic arthritis osteoarthritis lumbago
Date of first enrollment2009/07/01
Target sample size300
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)Administration of celecoxib Combined administration of celecoxib and rebamipide


Primary OutcomeAn incidence of gastrointestinal bleeding or endoscopic ulcer
Secondary Outcome

Key inclusion & exclusion criteria

Age minimum20years-old
Age maximumNot applicable
GenderMale and Female
Include criteria
Exclude criteriaHistory of gastrointestinal surgery Presence of gastroesophageal reflex disease (GERD) Presence of malignancy Presence of gastrointestinal bleeding or gastrointestinal ulcer Presence of aspirin-induced asthma Pcesence of severe cardiac disorder, renal disorder or liver disorder Impossibility of endoscopic examination Presence of allergy of celecoxib or rebamipide History of percutaneous coronary revascularization Pregnancy and lactation Impossibility of discontinuation of proton pump inhibitor or histamine-2 receptor antagonist Administration of NSAID that excludes aspirin Patient who doctor judged improper

Related Information


public contact
Name Kyosuke Tanaka
Address Japan
Affiliation Mie University Hospital Gastroenterology and Hepatology
scientific contact
Name Masahiro Hasegawa
Address 2-174 Edobashi, Tsu, Mie Japan Japan
Telephone 059-232-1111
Affiliation Mie University Hospital Orthopaedic Surgery