UMIN ID: UMIN000002031
Registered date:02/06/2009
Exploratory analysis of predictive and prognostic biomarkers in the randomized phase III study of FOLFOX plus bevacizumab versus FOLFIRI plus bevacizumab for metastatic colorectal cancer (WJOG4407GTR)
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | metastatic colorectal cancer |
| Date of first enrollment | 2009/06/01 |
| Target sample size | 200 |
| Countries of recruitment | Japan |
| Study type | Observational |
| Intervention(s) |
Outcome(s)
| Primary Outcome | 1) To correlate micro vascular density (MVD) and expression of VEGF-A in the tumor specimens with response rates (RR), progression free survival (PFS) and over all survival (OS). 2) To correlate expressions of various genes and k-Ras gene status in the tumor specimens with RR, PFS and OS. 3) To correlate the values of angiogenesis-related growth factors in plasma with RR, PFS and OS. 4) To correlate the profiles of glycoconjugates in plasma with RR, PFS and OS. |
|---|---|
| Secondary Outcome | Not applicable |
Key inclusion & exclusion criteria
| Age minimum | 20years-old |
|---|---|
| Age maximum | 75years-old |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | Not applicable |
Related Information
| Primary Sponsor | West Japan Oncology Group |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | None |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Shinichiro Nakamura |
| Address | Japan |
| Telephone | 06-6633-7400 |
| datacenter@wjog.jp | |
| Affiliation | West Japan Oncology Group WJOG datacenter |
| scientific contact | |
| Name | Junji Tsurutani |
| Address | 377-2 Ohnohigashi, Osakasayama, Osaka 589-8511 Japan Japan |
| Telephone | 072-366-022 |
| Affiliation | Kinki University School of Medicine Department of Medical Oncology |