NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
UMIN ID: UMIN000001950

Registered date:08/05/2009

The JOINT Study :Evaluation of effect and safty of Losartan/Hydrochlorothazide fixed dose combination for hypertensive patients

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedHypertension
Date of first enrollment2008/06/01
Target sample size400
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)Losartan/Hydrochlorothizide

Outcome(s)

Primary OutcomeChange in systolic and diastolic blood pressure after 3 months of treatment
Secondary OutcomeChange in home blood pressure, serum uric acid, microalbuminuria, BNP after 3 months of treatment Change in serum uric acid, microalbuminuria, BNP, medication cost after 6 months of treatment

Key inclusion & exclusion criteria

Age minimum20years-old
Age maximum75years-old
GenderMale and Female
Include criteria(1)Hypertensive patients, whose blood pressure has not been reached the target levels SBP>130mmHg or DBP>80mmHg. (2)Patients who have been treated by 1 to 3 antihypertensive drugs. (3)Outpatients (4)Men and women aged 20 to 75 years
Exclude criteria(1)Patiens with renal failure(serum creatinine >2.5 mg/dL (2)Patients with liver dysfunction [GPT(ALT) over three times the normal value] (3)Pregnant or possible pregnant women (4)Breast-feeding women (5)Patients who are considered not eligible for the study by the attending doctor due to medical reasons

Related Information

Contact

public contact
Name Iwao Ohno
Address 3-25-8 Nishi-Shinbashi Minato-ku Tokyo Japan
Telephone 03-3433-1111
E-mail i-ohno@jikei.ac.jp
Affiliation Jikei University School of Medicine Division of Kidney and Hypertension
scientific contact
Name Tatsuo Hosoya
Address 3-25-8 Nishi-Shinbashi Minato-ku Tokyo Japan
Telephone 03-3433-1111
E-mail
Affiliation Jikei University School of Medicine Division of Kidney and Hypertension