UMIN ID: UMIN000001890
Registered date:20/04/2009
Clinical trial to investigate the effect of candesartan on QOL and geriatric syndome in elderly hypertensive patients
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | essential hypertension |
| Date of first enrollment | 2009/04/01 |
| Target sample size | 1000 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | Candesartan will be replaced with calcium channel blockers (Group A), or will be added to calcium channel blockers (Group B), depending on the blood pressure control as decided by attending physician. Candesartan can be increased up to 12 mg/day according to blood pressure. |
Outcome(s)
| Primary Outcome | Changes of QOL questionnaire score (SF-8) |
|---|---|
| Secondary Outcome | 1) Subjective symptoms of the geriatric syndrome questionnaire. 2) Office blood pressure and pulse rate. 3) Home blood pressure and pulse rate |
Key inclusion & exclusion criteria
| Age minimum | 65years-old |
|---|---|
| Age maximum | Not applicable |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | 1) Subjects with irritation to candesartan 2) Subjects with (possible) pregnancy 3) Subejects with renal artery stenosis 4) Subjects with hyperkalemia 5) Subjects taking any angiotensin receptor blockers 6) Subjects who are unable to fill out the questionnaire 7) Other ineligible subjects |
Related Information
| Primary Sponsor | Department of Geriatric Medicine, University of Tokyo Hospital |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Department of Geriatric Medicine, University of Tokyo Hospital |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Masahiro Akishita |
| Address | Japan |
| Telephone | |
| Affiliation | University of Tokyo Hospital Department of Geriatric Medicine |
| scientific contact | |
| Name | Yasuyoshi Ouchi |
| Address | 7-3-1 Hongo, Bunkyo-ku Tokyo Japan |
| Telephone | 03-3815-5411 |
| Affiliation | University of Tokyo Hospital Department of Geriatric Medicine |