NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
UMIN ID: UMIN000001866

Registered date:10/04/2009

Continuous intravenous infusion therapy with cyclosporine A for rapidly progressive interstitial pneumonia associated with dermatomyositis and polymyositis

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedDermatomyositis or polymyositis with interstitial pneumonia
Date of first enrollment2009/04/01
Target sample size10
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)(1)The patients are initially treated with methylprednisolone (m-PSL) pulse (1000 mg daily for three days) followed by oral prednisolone (1mg/kg daily). (2)Continuous intravenous CyA (2 mg/kg daily for initial dose) is started following m-PSL pulse therapy, and the dosage will be adjusted to a level of 200-300ng/ml.

Outcome(s)

Primary OutcomeClinical symptoms, Respiratory functional evaluation, Chest CT and X-ray, Blood examinations
Secondary OutcomeTo evaluate long-term prognosis To establish an effective therapeutic strategy

Key inclusion & exclusion criteria

Age minimum16years-old
Age maximumNot applicable
GenderMale and Female
Include criteria
Exclude criteriaWe exclude patients with active infectious disease, severe renal dysfunction and malignancy.

Related Information

Contact

public contact
Name Yasuhiro Shimojima
Address 3-1-1 Asahi, Matsumoto, Japan Japan
Telephone 0263-37-2673
E-mail yshimoji@shinshu-u.ac.jp
Affiliation Shinshu University School of Medicine Department of Neurology and Rheumatology
scientific contact
Name Yasuhiro Shimojima
Address 3-1-1 Asahi, Matsumoto, Japan Japan
Telephone 0263-37-2673
E-mail yshimoji@shinshu-u.ac.jp
Affiliation Shinshu University School of Medicine Department of Neurology and Rheumatology