Investigation of effective treatment of nocturnal hypertension in diabetes

UMIN ID: UMIN000001802

Registered date:01/07/2009

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: Nocturnal hypertension in type 2 DM
• Date of first enrollment: 2009/07/01
• Target sample size: 50
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Losartan / hydrochlorothiazide group
ARB and CCB group

Outcome(s)

• Primary Outcome: Change in nocturnal blood pressure level after 12 weeks of treatment
• Secondary Outcome: change in blood pressure level on an outpatient basis after 4,8 weeks of treatment change after12 weeks about HbA1c, fasting bllod glucose level, urine alubimin excretion, Urine Na, Crine K, renin, aldsterone, BNP, serum K, serum Na, serum UA, serum Creatinine, eGFR, LDL-C, TG, HDL-C

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: 1) patients with secondary hypertension 2) patients with liver dysfunction (GPT over three times the normal value) 3) patients with renal failure (serum creatinine over 2.0 mg/dL) 4) patients with bilareral renal artery stenosis 5) pregnant or possible pregnant women 6) patients with a history of hypersensitivity to Losartan or thiazide

Related Information

• Primary Sponsor: Kobe University Graduate School of Medicine Division of deabetes, metabolism and endocrinology
• Source(s) of Monetary Support: Division of deabetes, metabolism and endocrinology Kobe University Graduate School of Medicine