NIPH Clinical Trials Search

UMIN ID: UMIN000001792

Registered date:24/03/2009

Effect of landiolol hydrochloride for prevention of atrial fibrillation after CABG: a randomised controlled trial

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedmyocardial infarction, angina
Date of first enrollment2008/10/01
Target sample size140
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)intra-and perioperative administration of landiolol hydrochloride intra-and perioperative non-administration of landiolol hydrochloride


Primary OutcomeIncidence of postoperative atrial fibrillation
Secondary Outcome1) age 2) Blood pressure, heart rate, CVP 3) IL-6, IL-8 4) CK-MB, Tp-I, H-FABP 5) Urinary-OHdG 6) hyaluronan, KL-6, angiotensin-II 7) mortality, complication

Key inclusion & exclusion criteria

Age minimum20years-old
Age maximum90years-old
GenderMale and Female
Include criteria
Exclude criteriapast of arrhythmia cardiogenic shock NYHA class IV congestive heart failure despite treatment sinus bradycardia at rest (<50/min) second -or third-degree AV block clinical hypothyroidism or hyperthyroidism Doctor's decision not to register to this regimen

Related Information


public contact
Address Japan
Affiliation Nihon University School of Medicine Department of Cardiovascular Surgery
scientific contact
Name Akira Sezai
Address 30-1 Oyaguchi kami-machi, Itabashi-ku, Tokyo, Japan Japan
Telephone 03-3972-8111
Affiliation Nihon University school of medicine Department of Cardiovascular Surgery