UMIN ID: UMIN000001739
Registered date:27/02/2009
The influence of azelnidipine on plasma renin activity and plasma aldosterone concentration in hypertensive patients.
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | Essential hypertension |
| Date of first enrollment | 2007/10/01 |
| Target sample size | 40 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | PRA/PAC was measured in 10 of essential hypertensive patients. Then, 16 mg of azelnidipine a day was started to administer for 4 weeks. After this period, PRA/PAC was measured again. PRA/PAC was measured in 10 of essential hypertensive patients who have been treated with amlodipine. Then, 16 mg of azelnidipine a day was started to administer in stead of amlodipine for 4 weeks. After this period, PRA/PAC was measured again. PRA/PAC was measured in 10 of essential hypertensive patients who have been treated with manidipine. Then, 16 mg of azelnidipine a day was started to administer in stead of manidipine for 4 weeks. After this period, PRA/PAC was measured again. PRA/PAC was measured in 10 of essential hypertensive patients who have been treated with nifedipine. Then, 16 mg of azelnidipine a day was started to administer in stead of nifedipine for 4 weeks. After this period, PRA/PAC was measured again. |
Outcome(s)
| Primary Outcome | Plasma renin activity, plasma aldosterone concentration |
|---|---|
| Secondary Outcome |
Key inclusion & exclusion criteria
| Age minimum | 50years-old |
|---|---|
| Age maximum | 90years-old |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | Secondary hypertension |
Related Information
| Primary Sponsor | Graduate School of Medical Sciences, Kumamoto University |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Graduate School of Medical Sciences, Kumamoto University |
| Secondary ID(s) |
Contact
| public contact | |
| Name | |
| Address | 1-1-1, Honjo, Kumamoto Japan |
| Telephone | 096-373-5169 |
| Affiliation | Graduate School of Medical Sciences, Kumamoto University Department of Metabolic Medicine |
| scientific contact | |
| Name | Tatsuya Kondo |
| Address | 1-1-11-1-1, Honjo, Kumamoto Japan |
| Telephone | |
| Affiliation | Graduate School of Medical Sciences, Kumamoto University Department of Metabolic Medicine |