UMIN ID: UMIN000001720
Registered date:23/02/2009
Evaluation of the effect of Angiotensin ll receptor blocker for plaque vulnerability after percutaneous coronary intervention (PCI)
Basic Information
| Recruitment status | |
|---|---|
| Health condition(s) or Problem(s) studied | Hypertension with coronary artery disease |
| Date of first enrollment | 2009/02/01 |
| Target sample size | 40 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | Telmisartan + Pravastatin sodium Antiypertensive agents except RAS blocker + Pravastatin sodium |
Outcome(s)
| Primary Outcome | Change in plaque composition and observation by Integrated Backscatter Intravascular Ultrasound (IB-IVUS) |
|---|---|
| Secondary Outcome | 1) Change in surrogate marker in coronary vein blood hs-CRP,IL-6,TNF-alpha,IP-10,MMP-3, MMP-9,MCP-1,MIF,PTX-3,Heparin cofactor 2) Office blood pressure |
Key inclusion & exclusion criteria
| Age minimum | 20years-old |
|---|---|
| Age maximum | 80years-old |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | 1) Previous storoke<=6month 2) Ejection fraction<=40% 3) Patients with dialysis 4) Diabetic patients with HbA1c<=6.5 5) Patients who are treated with statin except pravastatin sodium |
Related Information
| Primary Sponsor | The University of Tokushima, Cardiovascular Medicine |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | None |
| Secondary ID(s) |
Contact
| public contact | |
| Name | |
| Address | Japan |
| Telephone | 088-633-7852 |
| Affiliation | The University of Tokushima Institute of Health Biosciences Graduate School Cardiovascular Medicine |
| scientific contact | |
| Name | Masataka SATA |
| Address | 3-18-15 Kuramoto-Cho Tokushima Japan |
| Telephone | |
| Affiliation | The University of Tokushima Cardiovascular Medicine |