Influence of maternal xylitol consumption from pregnancy on mother-child transmission of cariogenic bacteria and caries occurrence of the infants.

UMIN ID: UMIN000001690

Registered date:10/02/2009

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: dental caries
• Date of first enrollment: 2003/12/01
• Target sample size: 92
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

The mothers in Xyl group received basic prevention such as oral hygiene instructions and professional tooth cleaning at 6th month of pregnancy. In Xyl group, maternal gum chewing started at 6th month of the pregnancy and terminated 13 mos later when their children were 9 mos of age. Children in both groups had never been intervened at all.
The mothers in Control group received basic prevention such as oral hygiene instructions and professional tooth cleaning at 6th month of pregnancy (the same way as Xyl group).

Outcome(s)

• Primary Outcome: MS colonization was assessed the presence of bacterial growth on the strip and site strip in the children aged 6, 9, 12, 18, and 24 months (Dentocult SM).
• Secondary Outcome: Salivery MS levels of the mothers during intervention for 13 months and as well as for 15 months after cessation of the intervention(Dentocult SM).

Key inclusion & exclusion criteria

• Age minimum: Not applicable
• Age maximum: Not applicable
• Gender: Female
• Exclude criteria: Individuals with a history of regular antibiotics medication or GI problem.

Related Information

• Primary Sponsor: Dept. of Behavioral Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
• Source(s) of Monetary Support: Ministry of Education, Culture, Sports, Science and Technology (Grant-in-Aid for Scientific research)