UMIN ID: UMIN000001671
Registered date:01/02/2009
The comparative study of the effects of miglitol and voglibose (alpha-glucosidase inhibitors) on incretins secretion
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | type-2 diabetes |
| Date of first enrollment | 2008/12/01 |
| Target sample size | 40 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | miglitol 50 mg thrice a day voglibose 0.3 mg thrice a day |
Outcome(s)
| Primary Outcome | Coparisons of changes in plasma glucose, insulin, GLP-1 and GIP in response to a mixed meal before and after administration of miglitol or voglibose. |
|---|---|
| Secondary Outcome | HbA1c, body weight, BMI, serum levels of adiponectin, high-sense CRP and MCP-1 at baseline and 3 month aftrer administrations of miglitol or voglibose. |
Key inclusion & exclusion criteria
| Age minimum | 20years-old |
|---|---|
| Age maximum | 80years-old |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | 1) type-1 diabetes 2) severe hepatic or renal disease 3) severe heart disease 4) having canceres 5) unstable diabetic retinpathy 6) having a condyion to be worsened by increase in intestinal gas 7) a woman who is nursing or pregnant 8) after gstrectomy 9) a patient who is judged as not appropriate for participation |
Related Information
| Primary Sponsor | Akita University School of Medicine Department of Endocrinology, Diabetes and Geriatric Medicine |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | No |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Takuma Narita |
| Address | Japan |
| Telephone | |
| narita@med.akita-u.ac.jp | |
| Affiliation | Akita University School of Medicine Department of Endocrinology, Diabetes and Geriatric Medicine |
| scientific contact | |
| Name | Takuma Narita |
| Address | 1-1-1 Hondo, Akita-city, Japan Japan |
| Telephone | |
| Affiliation | Akita University School of Medicine Department of Endocrinology, Diabetes and Geriatric Medicine |