A randomized controlled trial for low-dose continuous Infusion of human atrial natriuretic peptide for cardiac dysfunction undergoing cardiac surgery

UMIN ID: UMIN000001652

Registered date:23/01/2009

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: myocardial infarction, angina
• Date of first enrollment: 1997/03/01
• Target sample size: 130
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Perioperative administration of hANP
Perioperative non-administration of hANP

Outcome(s)

• Primary Outcome: Early postoperative outcome(mortality and complications) Long-term results(cardiac death-and events-free rate, overall survival rate after surgery))
• Secondary Outcome: cardiac function(UCG, BNP) renal function (sCr,eGFR,Maximum sCr,Increase of Cr,(pre-max. sCr) > 0.3 mg/dl) ANP, renin, anigotensin-II, aldsterone

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 90years-old
• Gender: Male and Female
• Exclude criteria: cardiogenic shock renal dysfunction with hemodyalysis

Related Information

• Primary Sponsor: Nihon University School of Medicine
• Source(s) of Monetary Support: self funding,a grant for the 60th anniversary of the Alumni Association of Nihon University School of Medicine and for the 50th anniversary of the foundation of Nihon University School of Medicine.