UMIN ID: UMIN000001647
Registered date:20/01/2009
A prospective study of Trimethoprime-sulfamethoxazole(TMP/SMX) for prevention of Pneumocystis pneumonia(PCP) in patients under immunosuppressive therapy
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | The patients with rheumatic diseases who are receiving more than 30mg/day of prednisolone |
| Date of first enrollment | 2008/04/01 |
| Target sample size | 60 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | Daily a week administration of a TMP/SMX(Bacter) tablet Twice a week administration of a TMP/SMX(Bacter) tablet |
Outcome(s)
| Primary Outcome | Incidence of PCP |
|---|---|
| Secondary Outcome | 1)Positive rate of Pneumocystis polymerase chain reaction in sputum 2)Incidence of the increased plasma level of beta-D-gulucan |
Key inclusion & exclusion criteria
| Age minimum | 20years-old |
|---|---|
| Age maximum | 75years-old |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | 1.On TMP/SMX 2.Suffering from PCP 3.Complicated with serious liver and/or renal disfunction,cytopenia 4.Allergy to TMP/SMX 5.Pregnant,and/or nursing 6.In approppriate patients decided by doctors |
Related Information
| Primary Sponsor | Division of Rheumatology,Department of Internal Medicine,Toho University School of Mdicine,Tokyo,Japan |
|---|---|
| Secondary Sponsor | None |
| Source(s) of Monetary Support | Toho University School of Mdicine,None |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Shinichi Kwai |
| Address | 6-11-1 Omori-Nishi, Ota-ku Tokyo 143-8541,Japan. Japan |
| Telephone | 03-3762-4151(ext.6591) |
| skawai@med.toho-u.ac.jp | |
| Affiliation | Department of Internal Medicine, Toho University School of Mdicine, Tokyo,Japan Division of Rheumatology |
| scientific contact | |
| Name | Shinichi Kwai |
| Address | 6-11-1 Omori-Nishi, Ota-ku Tokyo 143-8541,Japan Japan |
| Telephone | 03-3762-4151(ext.6591) |
| Affiliation | Department of Internal Medicine, Toho University School of Mdicine Division of Rheumatology |