UMIN ID: UMIN000001593
Registered date:22/12/2008
Therapeutic effects of L/N type calcium channel blocker cilnidipine and L type calcium channel blockers on hypertensive patients with chronic kidney disease
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | Hypertension, Chronic kidney disease |
| Date of first enrollment | 2008/12/01 |
| Target sample size | 60 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | Cilnidipine (L/N) group: Change already prescribed calcium channel blockers other than cilnidipine to daily dosing of cilnidipine 10 mg daily for 48 weeks, and dosage may be modulated accroding to the clinical parameters (cilnidipine 5-20 mg daily). Target blood pressure level is below 130/80 mmHg. Control (L) group: Continue already prescribed calcium channel blockers other than cilnidipine for 48 weeks, and dosage may be modulated accroding to the clinical parameters. Target blood pressure level is below 130/80 mmHg. |
Outcome(s)
| Primary Outcome | 1. Clinic blood pressure. 2. Ambulatory blood pressure monitoring. 3. Renal function: eGFR, urinary protein/albuminon excretion. 4. Renin-angiotensin system, inflammatory and oxidative stress markers, PRA, urinary angiotensinogen, plasma cathecholamine. 5. Cardiac function: BNP, UCG. 6. Vascular function: ABI/baPWV. |
|---|---|
| Secondary Outcome |
Key inclusion & exclusion criteria
| Age minimum | 20years-old |
|---|---|
| Age maximum | Not applicable |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | 1. Patients already treated with cilnidipine, 2. History of hypersensitivity to cilnidipine, 3. Severe hypertension (clinic BP more than 180/100 mmHg), 4. Severe liver disorder, or severe biliary atresia, 5. Pregnant women, or women suspected of being pregnant. |
Related Information
| Primary Sponsor | Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Satoshi UMEMURA |
| Address | 3-9 Fukuura, kanazawa-ku, Yokohama 236-0004, Japan Japan |
| Telephone | 045-787-2633 |
| sumemura@med.yokohama-cu.ac.jp | |
| Affiliation | Yokohama City University Graduate School of Medicine Deaprtment of Medical Science |
| scientific contact | |
| Name | Kouichi TAMURA |
| Address | 3-9 Fukuura, kanazawa-ku, Yokohama 236-0004, Japan Japan |
| Telephone | 045-787-2635 |
| Affiliation | Yokohama City University Graduate School of Medicine Deaprtment of Medical Science |