NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
UMIN ID: UMIN000001535

Registered date:01/01/2009

A multicenter, randomized open trial of ascorbic acid treatment in Charcot-Marie-Tooth disease type 1A

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedCharcot-Marie-Tooth disease 1A
Date of first enrollment2005/04/01
Target sample size60
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)Ascorbic acid (AA) treatment group (12 weeks oral AA (20mg/kg/day) no AA treatment group

Outcome(s)

Primary OutcomeAn improvement in CMT neuropathy score at baseline, 4, 8 and 12 weeks thereafter.
Secondary OutcomeAn improvement in muscle strength and ulnar nerve conduction study at baseline, 4, 8 and 12 weeks thereafter.

Key inclusion & exclusion criteria

Age minimum15years-old
Age maximum75years-old
GenderMale and Female
Include criteria1) CMT1A patients with PMP duplications (triple gene doses) 2) Patients with normal function of main organs (heart, lung, liver and kidney) 3) Patients with no severe complications
Exclude criteria1) Patients with dementia 2) Patients with severe complications 3) Patients who are not appropriate for the trial by the decision of the physician in charge

Related Information

Contact

public contact
Name Masanori Nakagawa
Address Kawaramachi Hirokoji, Kajii-chou 465, Kamigyo-ku, Kyoto 602-0841, Japan Japan
Telephone 075-251-5793
E-mail mnakagaw@koto.kpu-m.ac.jp
Affiliation Kyoto Prefectural University of Medicine, Graduate School of Medical Science Department of Neurology
scientific contact
Name Masanori Nakagawa
Address Kawaramachi Hirokoji, Kajii-chou 465, Kamigyo-ku, Kyoto 602-0841, Japan Japan
Telephone 075-251-5793
E-mail
Affiliation Kyoto Prefectural University of Medicine, Graduate School of Medical Science Department of Neurology