Clinical trial with ghrelin for patients with chronic respiratory failure

UMIN ID: UMIN000001512

Registered date:01/12/2008

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: chronic respiratory failure
• Date of first enrollment: 2008/12/01
• Target sample size: 50
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Human ghrelin (1 microgram/kg, 10 mL solution) was intravenously administered to the patients for 30 min at a constant rate before breakfast and dinner for 3 weeks continuously.
Human ghrelin (2 microgram/kg, 10 mL solution) was intravenously administered to the patients for 30 min at a constant rate before breakfast and dinner for 3 weeks continuously.

Outcome(s)

• Primary Outcome: 6-min walking distance

Key inclusion & exclusion criteria

• Age minimum: Not applicable
• Age maximum: 80years-old
• Gender: Male and Female
• Exclude criteria: 1)patient with cancer (and/or post-operative state), lymphangiomyomatosis, lymphoproliferative disease, collagen lung, neuromuscular disease, primary hypoventilation syndrome, pneumoconiosis, eosinophilic granulomatosis, and/or diffuse panbronchiolitis 2)patient with diabetes mellitus (HbA1c>8.0) 3)patient with severe heart disease 4)patient with liver dysfunction 5)patient with renal dysfunction 6)pregnant woman 7)patient with dementia

Related Information

• Primary Sponsor: University of Miyazaki
• Source(s) of Monetary Support: Ministry of Health, Labour and Welfare