Effects of extract of decaffeinated green coffee beans on postprandial serum glucose in healthy subjects.

UMIN ID: UMIN000001493

Registered date:10/11/2008

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: hyperglycemia
• Date of first enrollment: 2007/05/01
• Target sample size: 45
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

1) A total of 41 subjects (22 men and 19 women ) without type 2 diabetes were enrolled in the present study. 2) Test meals of 200g of a carbohydrate-rich meal plus placebo (200ml) were administered in a double-blind trial. 3) Antecubital venous blood was collected before the meal and at t = 0.5, 1, 1.5 and 2 h, where t = 0 was the start of test meal ingestion.
1) A total of 41 subjects (22 men and 19 women ) without type 2 diabetes were enrolled in the present study. 2) Test meals of 200g of a carbohydrate-rich meal plus extract of decaffeinated green coffee beans (100mg/200ml water) were administered in a double-blind trial. 3) Antecubital venous blood was collected before the meal and at t = 0.5, 1, 1.5 and 2 h, where t = 0 was the start of test meal ingestion.
1) A total of 41 subjects ( 22 men and 19 women ) without type 2 diabetes were enrolled in the present study. 2) Test meals of 200g of a carbohydrate-rich meal plus extract of decaffeinated green coffee beans (300mg/200ml water) were administered in a double-blind trial. 3) Antecubital venous blood was collected before the meal and at t = 0.5, 1, 1.5 and 2 h, where t = 0 was the start of test meal ingestion.

Outcome(s)

• Primary Outcome: 1) Postprandial serum glucose (0,30,60,90, and 120min) and AUC (0-120min) 2) Postprandial serum insulin (0,30,60,90, and 120min) and AUC (0-120min)

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 50years-old
• Gender: Male and Female
• Exclude criteria: 1) Individuals who do not usually eat breakfast. 2) Individuals taking drugs which affect the glucose level. 3) Individuals taking supplements which improve the glucose level. 4) Individuals judged to have diabetes mellitus. 5) Individuals with serious complications or with a disease which urgently needs treatment. 6) Individuals with a chronic disease. 7) Individuals with a digestive system disease and with a history of digestive organ surgery. 8) Individuals with a medical record of drug or alcohol dependence. 9) Pregnant women, or women with intending to become pregnant, and lactating women. 10) Individuals participating or intending to participate in a drug administration test. 11) Individuals judged by the doctor to be unsuitable.

Related Information

• Primary Sponsor: UCC Ueshima Coffee, Co., Ltd.
• Source(s) of Monetary Support: None