UMIN ID: UMIN000001492
Registered date:11/11/2008
Pharmacogenetic study on the influence of aldehyde dehydrogenase 2 (ALDH2) gene polymorphism on the vasodilatation induced by organic nitrates
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | angina pectoris |
| Date of first enrollment | 2008/12/01 |
| Target sample size | 72 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | nitroglycerin isosorbide dinitrate |
Outcome(s)
| Primary Outcome | Ratio of maximal increase in brachial artery diameter Time to attain maximal and 90% maximal dilatation of brachial artery |
|---|---|
| Secondary Outcome | Pulse rate, blood pressure, and their post/pre-administration ratios |
Key inclusion & exclusion criteria
| Age minimum | 20years-old |
|---|---|
| Age maximum | 39years-old |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | History of cardiovascular diseases Serious liver damages Serious renal damages Pregnant women History of adverse reaction to organic nitrates Persons using sildenafil, vardenafil, or tadalafil Systolic blood pressure less than 90 mmHg Body weight less than 40 kg or more than 90 kg Persons considered to be unsuitable to the study |
Related Information
| Primary Sponsor | Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Ministry of Education, Culture, Sports, Science and Technology |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Toshiyuki Sasaguri |
| Address | 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan Japan |
| Telephone | 092-642-6080 |
| sasaguri@med.kyushu-u.ac.jp | |
| Affiliation | Faculty of Medical Sciences, Kyushu University Department of Clinical Pharmacology |
| scientific contact | |
| Name | Toshiyuki Sasaguri |
| Address | 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan Japan |
| Telephone | 092-642-6080 |
| Affiliation | Faculty of Medical Sciences, Kyushu University Department of Clinical Pharmacology |