NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
UMIN ID: UMIN000001477

Registered date:03/11/2008

effect of latanoprost and travoprost on keratoconjunctiva l tissue

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedglaucoma
Date of first enrollment2008/10/01
Target sample size240
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)latanoprost 0.005% including benzalconium chloride preservative 3 months treatment once daily travoprost 0.004% including SofZia preservative 3 months treatment once daily

Outcome(s)

Primary Outcomethe damage of corneal and conjunctival epithelium, and conjunctival hyperemia at 1 and 3 months after application of 2 kinds of IOP-lowering eye drops including a different preservative in each solution
Secondary Outcomethe change of intraocular pressure at 1 and 3 months after application of 2 kinds of IOP-lowering eye drops including a different preservative in each solution

Key inclusion & exclusion criteria

Age minimum20years-old
Age maximum99years-old
GenderMale and Female
Include criteria
Exclude criteria1. the eyes with chronic or recurrent uveitis, scleritis, corneal herpes infection 2. the eyes with the history of trauma, intraocular surgery, or Laser surgery within 6 months 3. the eyes with difficulty for the measurement of IOP with the applanation tonometer 4. the subjects with the allergy for PG-analogues or benzalconium chloride 5. the subjects using the eyedrops excluding those in this study 6. the subjects treated with oral carbonic anhydrase inhibitor 7. the subject with Sjogren syndrome 8. the subjects who can not drop periodically 9. the subjects with the advanced glaucoma or the terminal stage of glaucoma 10. the subjects with the severe ocular complications

Related Information

Contact

public contact
Name makoto aihara
Address Japan
Telephone 03-5800-8906
E-mail
Affiliation University of Tokyo Hospital ophthalmology
scientific contact
Name makoto aihara
Address 7-3-1 Hongo Bunkyo Tokyo, Japan Japan
Telephone 03-3815-5411
E-mail
Affiliation university of Tokyo Ophthalmology