effect of latanoprost and travoprost on keratoconjunctiva l tissue

UMIN ID: UMIN000001477

Registered date:03/11/2008

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: glaucoma
• Date of first enrollment: 2008/10/01
• Target sample size: 240
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

latanoprost 0.005% including benzalconium chloride preservative 3 months treatment once daily
travoprost 0.004% including SofZia preservative 3 months treatment once daily

Outcome(s)

• Primary Outcome: the damage of corneal and conjunctival epithelium, and conjunctival hyperemia at 1 and 3 months after application of 2 kinds of IOP-lowering eye drops including a different preservative in each solution
• Secondary Outcome: the change of intraocular pressure at 1 and 3 months after application of 2 kinds of IOP-lowering eye drops including a different preservative in each solution

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 99years-old
• Gender: Male and Female
• Exclude criteria: 1. the eyes with chronic or recurrent uveitis, scleritis, corneal herpes infection 2. the eyes with the history of trauma, intraocular surgery, or Laser surgery within 6 months 3. the eyes with difficulty for the measurement of IOP with the applanation tonometer 4. the subjects with the allergy for PG-analogues or benzalconium chloride 5. the subjects using the eyedrops excluding those in this study 6. the subjects treated with oral carbonic anhydrase inhibitor 7. the subject with Sjogren syndrome 8. the subjects who can not drop periodically 9. the subjects with the advanced glaucoma or the terminal stage of glaucoma 10. the subjects with the severe ocular complications

Related Information

• Primary Sponsor: public health research foundation
• Source(s) of Monetary Support: public health research foundation