NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
UMIN ID: UMIN000001466

Registered date:29/10/2008

Influence of spironolactone or eplerenone on renin-angiotensin-aldosterone system and left ventricular remodeling after cardiac surgery

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedmyocardial infarction, angina
Date of first enrollment2007/12/01
Target sample size300
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)postoperative administration of spironolactone postoperative administration of eplerenone postoperative non-administration of spironolactone or eplerenone

Outcome(s)

Primary Outcomelong-term result cardiac event
Secondary OutcomeUCG (EF, LVDd, LVDs) BNP renin, angiotensin, aldosterone

Key inclusion & exclusion criteria

Age minimum20years-old
Age maximum80years-old
GenderMale and Female
Include criteria
Exclude criteriapreoperativerenal impairment(Cr>1.3mg/dl) preoperative cardiogenic shock

Related Information

Contact

public contact
Name Akira Sezai
Address 30-1 Oyagichi kami-machi, Itabashi-ku, Tokyo Japan
Telephone 03-3972-8111
E-mail asezai.med@gmail.com
Affiliation Nihon University School of Medicine Department of Cardiovascular Surgery
scientific contact
Name Akira Sezai
Address 30-1 Oyaguchi kami-machi, Itabashi-ku, Tokyo, Japan Japan
Telephone 03-3972-8111
E-mail asezai.med@gmail.com
Affiliation Nihon University School of Medicine Department of Cardiovascular Surgery