UMIN ID: UMIN000001466
Registered date:29/10/2008
Influence of spironolactone or eplerenone on renin-angiotensin-aldosterone system and left ventricular remodeling after cardiac surgery
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | myocardial infarction, angina |
| Date of first enrollment | 2007/12/01 |
| Target sample size | 300 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | postoperative administration of spironolactone postoperative administration of eplerenone postoperative non-administration of spironolactone or eplerenone |
Outcome(s)
| Primary Outcome | long-term result cardiac event |
|---|---|
| Secondary Outcome | UCG (EF, LVDd, LVDs) BNP renin, angiotensin, aldosterone |
Key inclusion & exclusion criteria
| Age minimum | 20years-old |
|---|---|
| Age maximum | 80years-old |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | preoperativerenal impairment(Cr>1.3mg/dl) preoperative cardiogenic shock |
Related Information
| Primary Sponsor | Nihon University School of Medicine |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | self funding,a grant for the 60th anniversary of the Alumni Association of Nihon University School of Medicine and for the 50th anniversary of the foundation of Nihon University School of Medicine. |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Akira Sezai |
| Address | 30-1 Oyagichi kami-machi, Itabashi-ku, Tokyo Japan |
| Telephone | 03-3972-8111 |
| asezai.med@gmail.com | |
| Affiliation | Nihon University School of Medicine Department of Cardiovascular Surgery |
| scientific contact | |
| Name | Akira Sezai |
| Address | 30-1 Oyaguchi kami-machi, Itabashi-ku, Tokyo, Japan Japan |
| Telephone | 03-3972-8111 |
| asezai.med@gmail.com | |
| Affiliation | Nihon University School of Medicine Department of Cardiovascular Surgery |