Influence of angiotensin receptor blocker and angiotensin-Converting Enzyme on renin-angiotensin-aldosterone system and left ventricular remodeling after cardiac surgery

UMIN ID: UMIN000001464

Registered date:29/10/2010

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: myocardial infarction, angina
• Date of first enrollment: 2001/11/01
• Target sample size: 200
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

postoperative administration of ARB
postoperative administration of ACE-I
postoperative non-administration of ARB or ACE-I

Outcome(s)

• Primary Outcome: long-term result cardiac event
• Secondary Outcome: UCG (EF, LVDd, LVDs) BNP renin, angiotensin, aldosterone

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 80years-old
• Gender: Male and Female
• Exclude criteria: preoperativerenal impairment(Cr>1.3mg/dl) preoperative cardiogenic shock

Related Information

• Primary Sponsor: Nihon University School of Medicine
• Source(s) of Monetary Support: self funding,a grant for the 60th anniversary of the Alumni Association of Nihon University School of Medicine and for the 50th anniversary of the foundation of Nihon University School of Medicine.