Effective of hANP for cardiac surgery in patients with moderate to severe preoperative renal dysfunction without dialysis.

UMIN ID: UMIN000001462

Registered date:29/10/2008

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: myocardial infarction, angina, valvular disease, thoracic aortic aneurysm
• Date of first enrollment: 1997/03/01
• Target sample size: 100
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Perioperative administration of hANP
Perioperative non-administration of hANP

Outcome(s)

• Primary Outcome: presence of dialysis eGFR
• Secondary Outcome: mortality ,survival rate ,complication, BNP, ANP, renin activity, angiotensin II, aldosterone, blood urea reno-event free rate, nitrogen (BUN), Cr, sodium (Na), osmotic pressure (Osm),Urinary Na (U-Na), urinary Cr (U-Cr), and osmotic pressure (U-osm) creatinine clearance Ccr, fractional sodium excretion, free water clearance and renal failure index

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 80years-old
• Gender: Male and Female
• Exclude criteria: cardiogenic shock dialysis-dependent patient

Related Information

• Primary Sponsor: Nihon University School of Medicine
• Source(s) of Monetary Support: self funding,a grant for the 60th anniversary of the Alumni Association of Nihon University School of Medicine and for the 50th anniversary of the foundation of Nihon University School of Medicine.