UMIN ID: UMIN000001462
Registered date:29/10/2008
Effective of hANP for cardiac surgery in patients with moderate to severe preoperative renal dysfunction without dialysis.
Basic Information
Recruitment status | Complete: follow-up complete |
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Health condition(s) or Problem(s) studied | myocardial infarction, angina, valvular disease, thoracic aortic aneurysm |
Date of first enrollment | 1997/03/01 |
Target sample size | 100 |
Countries of recruitment | Japan |
Study type | Interventional |
Intervention(s) | Perioperative administration of hANP Perioperative non-administration of hANP |
Outcome(s)
Primary Outcome | presence of dialysis eGFR |
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Secondary Outcome | mortality ,survival rate ,complication, BNP, ANP, renin activity, angiotensin II, aldosterone, blood urea reno-event free rate, nitrogen (BUN), Cr, sodium (Na), osmotic pressure (Osm),Urinary Na (U-Na), urinary Cr (U-Cr), and osmotic pressure (U-osm) creatinine clearance Ccr, fractional sodium excretion, free water clearance and renal failure index |
Key inclusion & exclusion criteria
Age minimum | 20years-old |
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Age maximum | 80years-old |
Gender | Male and Female |
Include criteria | |
Exclude criteria | cardiogenic shock dialysis-dependent patient |
Related Information
Primary Sponsor | Nihon University School of Medicine |
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Secondary Sponsor | |
Source(s) of Monetary Support | self funding,a grant for the 60th anniversary of the Alumni Association of Nihon University School of Medicine and for the 50th anniversary of the foundation of Nihon University School of Medicine. |
Secondary ID(s) |
Contact
public contact | |
Name | Akira Sezai |
Address | 30-1 Oyaguchi kami-machi, Itabashi-ku, Tokyo, Japan Japan |
Telephone | 03-3972-8111 |
asezai.med@gmail.com | |
Affiliation | Nihon University School of Medicine Department of Cardiovascular Surgery |
scientific contact | |
Name | Akira Sezai |
Address | 30-1 Oyaguchi kami-machi, Itabashi-ku, Tokyo, Japan Japan |
Telephone | 03-3972-8111 |
Affiliation | Nihon University School of Medicine Department of Cardiovascular Surgery |