A randomized controlled trial for low-dose continuous Infusion of human atrial natriuretic peptide on cardiac function after cardiac surgery

UMIN ID: UMIN000001443

Registered date:20/10/2008

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: myocardial infarction, angina, valvular disease, thoracic aortic aneurysm
• Date of first enrollment: 1997/03/01
• Target sample size: 1000
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Perioperative administration of hANP
Perioperative non-administration of hANP

Outcome(s)

• Primary Outcome: cardiac event free rate
• Secondary Outcome: ANP, BNP, cGMP, renin, anigotensin-II, aldsterone Incidence of arrhythmia mortality lon-term results after surgey complication cardioac function(UCG) CK-MB, Toronin-I, H-FABP

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 90years-old
• Gender: Male and Female
• Exclude criteria: Patients from whom informed consent was not obtained

Related Information

• Primary Sponsor: Nihon University School of Medicine
• Source(s) of Monetary Support: self funding,a grant for the 60th anniversary of the Alumni Association of Nihon University School of Medicine and for the 50th anniversary of the foundation of Nihon University School of Medicine.