Influence of continuous infusion of low-dose human atrial natriuretic peptide on renal function during cardiac surgery

UMIN ID: UMIN000001440

Registered date:20/10/2008

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: myocardial infarction, angina, valvular disease, thoracic aortic aneurysm
• Date of first enrollment: 1997/03/01
• Target sample size: 700
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Perioperative administration of hANP
Perioperative non-administration of hANP

Outcome(s)

• Primary Outcome: mortality complication Incidence of postoperative acute renal failure maximum value and percent increase of Cr.
• Secondary Outcome: pre-op, 0,1,3,7 days after surgery: ANP, renin activity, angiotensin II, aldosterone, blood urea nitrogen (BUN), Cr, sodium (Na), osmotic pressure (Osm),Urinary Na (U-Na), urinary Cr (U-Cr), and osmotic pressure (U-osm) . pre-op, 0,1,3,7 days after surgery: creatinine clearance Ccr, fractional sodium excretion, free water clearance and renal failure index.

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 90years-old
• Gender: Male and Female
• Exclude criteria: renal impairment(Cr>1.3mg/dl) cardiogenic shock

Related Information

• Primary Sponsor: Nihon University School of Medicine
• Source(s) of Monetary Support: self funding,a grant for the 60th anniversary of the Alumni Association of Nihon University School of Medicine and for the 50th anniversary of the foundation of Nihon University School of Medicine.