NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
UMIN ID: UMIN000001440

Registered date:20/10/2008

Influence of continuous infusion of low-dose human atrial natriuretic peptide on renal function during cardiac surgery

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedmyocardial infarction, angina, valvular disease, thoracic aortic aneurysm
Date of first enrollment1997/03/01
Target sample size700
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)Perioperative administration of hANP Perioperative non-administration of hANP

Outcome(s)

Primary Outcomemortality complication Incidence of postoperative acute renal failure maximum value and percent increase of Cr.
Secondary Outcomepre-op, 0,1,3,7 days after surgery: ANP, renin activity, angiotensin II, aldosterone, blood urea nitrogen (BUN), Cr, sodium (Na), osmotic pressure (Osm),Urinary Na (U-Na), urinary Cr (U-Cr), and osmotic pressure (U-osm) . pre-op, 0,1,3,7 days after surgery: creatinine clearance Ccr, fractional sodium excretion, free water clearance and renal failure index.

Key inclusion & exclusion criteria

Age minimum20years-old
Age maximum90years-old
GenderMale and Female
Include criteria
Exclude criteriarenal impairment(Cr>1.3mg/dl) cardiogenic shock

Related Information

Contact

public contact
Name Akira Sezai
Address 30-1 Oyaguchi kami-machi, Itabashi-ku, Tokyo, Japan Japan
Telephone 03-3972-8111
E-mail asezai.med@gmail.com
Affiliation Nihon University School of Medicine Department of Cardiovascular Surgery
scientific contact
Name Akira Sezai
Address 30-1 Oyaguchi kami-machi, Itabashi-ku, Tokyo, Japan Japan
Telephone 03-3972-8111
E-mail asezai.med@gmail.com
Affiliation Nihon University School of Medicine Department of Cardiovascular Surgery