UMIN ID: UMIN000001431
Registered date:01/11/2008
Correlation between prognosis and expressions of Mcl-1(Myeloid cell leukemia-1) and Stat-3(signal transducers and activator of transcription-3) in patients with metastasized or recurrent gastrointestinal malignancy
Basic Information
| Recruitment status | Pending |
|---|---|
| Health condition(s) or Problem(s) studied | Unresectable and recurrent gastric or colorectal carcinoma |
| Date of first enrollment | 2008/11/01 |
| Target sample size | 40 |
| Countries of recruitment | Japan |
| Study type | Observational |
| Intervention(s) |
Outcome(s)
| Primary Outcome | Relationships between explession levels of apoptosis related proteins ( Mcl-1, Phospho-Stat3, Bcl-2, Bcl-xl, Bcl-xs, cIAP, cFLIP) and efficacy of chemotherapy. |
|---|---|
| Secondary Outcome | Expression level of apoptosis related protein and background of patients, pathological characters, location and types of cancers. |
Key inclusion & exclusion criteria
| Age minimum | 20years-old |
|---|---|
| Age maximum | 85years-old |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | Patient who is not willing to join the study |
Related Information
| Primary Sponsor | Keio University School of Medicine |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Keio University School of Medicine |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Motoko Izumiya, MD |
| Address | 35 Shinanomachi, Shinjuku-ku Tokyo 160-8582 Japan |
| Telephone | 03-3353-1211 |
| Affiliation | Keio University School of Medicine Department of Gastroenterology and Hepatology |
| scientific contact | |
| Name | Hajime Higuchi, MD, PhD. |
| Address | 35 Shinanomachi, Shinjuku-ku Tokyo 160-8582 Japan |
| Telephone | 03-3353-1211 |
| Affiliation | Keio University School of Medicine, Internal Medicine Department of gastroenterology and Hepatology |