Basic and clinical research of pathogenesis of hip pain

UMIN ID: UMIN000001335

Registered date:24/08/2008

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: Osteoarthritis of the hip Femoral neck fracture
• Date of first enrollment: 2008/08/01
• Target sample size: 50
• Countries of recruitment: Japan
• Study type: Observational

Outcome(s)

• Primary Outcome: In basic research, synovium, limbus, femoral head and acetabulum are stained with neuron-specific class III beta-tubulin (TuJ-1), isolectin B4 (IB4), calcitonin gene-related peptide (CGRP), transient receptor potential (TRP), tromyosin receptor kinase (Trk), tumor necrosis factor-alpha (TNFa), nuclear factor-kappa B (NFkB), and p55TNF receptor. Qualitative and quantitative assessments are performed between osteoarthritis and femoral neck fracture. In clinical research, distribution and incidence of hip pain are evaluated as well as referred pain. Association of hip pain, immunohistchemistry, and image findings are analyzed.

Key inclusion & exclusion criteria

• Age minimum: Not applicable
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: 1) Past history of hip trauma, osteonecrosis of the femoral head, rheumatoid arthritis, and rapidly destructive coxarthritis 2) Previous hip surgery 3) Heart failure, respiratory dysfunction, hepatic insufficiency, and renal failure 4) Unfavorable patient condition 5) Inappropriate patient

Related Information

• Primary Sponsor: Department of Orthopaedic Surgery, Graduate school of Medicine, Chiba University
• Source(s) of Monetary Support: None