UMIN ID: UMIN000001300
Registered date:11/08/2008
The effects of angiotensin II receptor blockers (ARBs) on oxidative stress and atherosclerosis in patients with hypertension.
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | Patients with hypertension |
| Date of first enrollment | 2005/11/01 |
| Target sample size | 120 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | ARBs (select one from the following agents) Olemesartan 10-40mg/day Losaratan 25-100mg/day Telmisaratn 20-80mg/day The assessement will be done at baseline, 3, 6 and 12 months after the treatment. Calcium channel antagonist Nefidipine (Adalat-CR) 20-40mg/day The assessement will be done at baseline, 3, 6 and 12 months after the treatment. |
Outcome(s)
| Primary Outcome | The effects of ARBs on the parameters listed below at baseline, 3, 6, and 12 months after the administrations. (1) Blood samples (lipid profiles, glucose tolerance, high-sensitive CRP, BNP, etc.) (2) Oxidative stress marker (8-OHdG, 8-isoprostane, etc.) (3) Electrocardiography (4) Echocardiography (5) Carotid ultrasonography (6) Pulse wave velocity |
|---|---|
| Secondary Outcome | Evaluation of newly developed oxidative stress marker, such as oxidative LDL (negatively charged LDL) and glutathionylated protein |
Key inclusion & exclusion criteria
| Age minimum | 40years-old |
|---|---|
| Age maximum | 85years-old |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | Severe liver, renal or respiratory diseases Active infectious and inflammatory diseases Acute phase of heart failure Unstable angina Secondary hypertension |
Related Information
| Primary Sponsor | Second Department of Internal Medicine, Nagasaki University School of Medicine |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | None |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Satoshi Ikeda |
| Address | 1-7-1 Sakamoto, Nagasaki Japan |
| Telephone | 095-819-7273 |
| sikeda@nagasaki-u.ac.jp | |
| Affiliation | Nagasaki University School of Medicine Second Department of Internal Medicine |
| scientific contact | |
| Name | Satoshi Ikeda |
| Address | 1-7-1 Sakamoto, Nagasaki Japan |
| Telephone | 095-819-7273 |
| Affiliation | Nagasaki University School of Medicine Second Department of Internal Medicine |