NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
UMIN ID: UMIN000001266

Registered date:25/07/2008

Therapeutic efficacy of ezetimibe for use minute lipid analyzer: LipoSEARCH in patients with nonalcoholic steatohepatitis (NASH) complicated with hyperlipidemia: a pilot study.

Basic Information

Recruitment status
Health condition(s) or Problem(s) studiedNonalcoholic steatohepatitis
Date of first enrollment2008/07/01
Target sample size10
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)administration of ezetimibe (10mg daily) in 24 weeks.

Outcome(s)

Primary OutcomeBefore and after 6 months of ezetimibe (10mg daily) to nonalcoholic statohepatitis (NASH) patients, we assessed liver lipid-metabolite alteration for use minute lipid analyzer: LipoSEARCH.
Secondary Outcomewe compared with hepatic histologic features,

Key inclusion & exclusion criteria

Age minimum20years-old
Age maximum80years-old
GenderMale and Female
Include criteria
Exclude criteriaa.The criteria for exclusion from participation in the study: history of hepatic disease, such as chronic hepatitis C or concurrent active hepatitis B (serum positive for hepatitis B surface antigen), autoimmune hepatitis, primary biliary cirrhosis (PBC), sclerosing cholangitis, hemochromatosis, alpha1-antitrypsin deficiency, Wilsons disease, and current or past consumption of more than 20 g of alcohol daily. b. None of the patients had any clinical evidence of hepatic decompensation, such as hepatic encephalopathy, ascites, variceal bleeding, or elevated serum bilirubin level to more than twofold the upper limit of normal.

Related Information

Contact

public contact
Name Koji Fujita
Address 3-9,fukuura,kanazawa-ku,yokohama,kanagawa,Japan Japan
Telephone 045-787-2640
E-mail kfujita@yokohama-cu.ac.jp
Affiliation Yokohama-city university hospital Division of Gastroenterology
scientific contact
Name Atsushi Nakajima
Address 3-9,fukuura,kanazawa-ku,yokohama,kanagawa,Japan Japan
Telephone 045-787-2640
E-mail
Affiliation Yokohama-city university hospital Division of Gastroenterology