To compare therapeutic effect of Glycyrrhizic Acid and H1-receptor antagonist for acute urticaria : a multicenter, prospective, single-blind, randomized controlled trial

UMIN ID: UMIN000001254

Registered date:17/07/2008

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: acute urticaria
• Date of first enrollment: 2007/07/01
• Target sample size: 60
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Intravenous H1-receptor antagonist (Chlorpheniramine Maleate)
Glycyrrhizic Acid injestion

Outcome(s)

• Primary Outcome: A visual analog scale (VAS) for pruritus as a patient's subjective measurement
• Secondary Outcome: Evaluation of the itch based on a new rating scale (a 'itch score'), a final global improvement rating

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 80years-old
• Gender: Male and Female
• Exclude criteria: Patients who are unreliable in following physicians' directives; did not use of any other H1-receptor antagonists, steroids, or antiallergy agent within 48 hours before entry; have no history of contraindication of H1-receptor antagonist, Glycyrrhizic Acid injestion, or similar articles; are pregnant or in lactation period; have to drive back home by oneself; and are in other conditions at the discretion of the individual physician

Related Information

• Primary Sponsor: Yuzawa Community Medical Center
• Secondary Sponsor: Tsukuba Medical Center Hospital
• Source(s) of Monetary Support: The Japanese Academy of Family Medicine