NIPH Clinical Trials Search

UMIN ID: UMIN000001139

Registered date:29/04/2008

Japan Morning Surge-Total Organ Protection: JMS-TOP Study

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedHypertension
Date of first enrollment2005/04/01
Target sample size450
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)Evening administration of angiotensin II receptor blocker (Candesartan) Morning administration of angiotensin II receptor blocker (Candesartan)


Primary OutcomeReduction of home morning blood pressure Improvements of hypertensive target organ damage measured as urinary albumin excretion ratio and brain-type natriuretic peptide
Secondary OutcomeChanges in 24-hr blood pressure Changes in left ventricular hypertrophy(electrocardiogram and echocardiography), left ventricular diastolic function, carotid intima-media thickness, pulse wave velocity, augmentation index and baroreflex sensitivity

Key inclusion & exclusion criteria

Age minimumNot applicable
Age maximumNot applicable
GenderMale and Female
Include criteria
Exclude criteria1) Recent history (within 6 months) of ischemic heart disease, stroke (excluding transient ischemic attack), aortic dissection, and peripheral arterial disease. 2) History of admission due to heart failure 3) On hemodialysis 4) Chronic inflammatory disease (cancer, collagen disease) 5) Subjects who are difficult to get informed consent 6) Subjects who are unable to visit to hospitals/clinics 7) History of adverse effect with candesartan, and contraindications of candesartan 8) Atrial fibrillation 9) Bilateral renal arterial stenosis

Related Information


public contact
Name Satoshi Hoshide, Joji Ishikawa
Address Yakushiji 3311-1, Shimotsuke, Tochigi 320-0498, Japan Japan
Telephone 0285-44-2130
Affiliation JMS-TOP study coordinator Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medi
scientific contact
Name Kazuomi Kario
Address Yakushiji 3311-1, Shimotsuke, Tochigi, Japan Japan
Telephone 0285-44-2111
Affiliation Jichi Medical University Division of Cardiovascular Medicine