UMIN ID: UMIN000001058
Registered date:28/02/2008
Study of SNPs effect of Cytochrome P450 and Vitamine K related enzyme on PK/PD of warfarine
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | atrial fibrillarion, pulmonary embolism, deep vein thronbosis, heart failure, stroke and other cardiovascular diseases |
| Date of first enrollment | 2008/03/01 |
| Target sample size | 300 |
| Countries of recruitment | Japan |
| Study type | Observational |
| Intervention(s) |
Outcome(s)
| Primary Outcome | To evaluate the difference between four groups defined by SNPs of P450 and vitamin K related enzyme with PK/PD of warfarin and vitamin K concentration in the blood. |
|---|---|
| Secondary Outcome | To evaluate the difference between four groups defined by SNPs of P450 and vitamin K related enzyme with retrospectively collected warfarin PD data as long term therapy. |
Key inclusion & exclusion criteria
| Age minimum | 15years-old |
|---|---|
| Age maximum | Not applicable |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | None. |
Related Information
| Primary Sponsor | St. Marianna University School of Medicine |
|---|---|
| Secondary Sponsor | RIKEN Yokohama Institute |
| Source(s) of Monetary Support | St. Marianna University School of Medicine |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Naoki Matsumoto |
| Address | 2-16-1 Sugao, Miyamae-ward, Kawasaki, 216-8511 Japan Japan |
| Telephone | 044-977-8111 |
| matsumoto@marianna-u.ac.jp | |
| Affiliation | St. Marianna University School of Medicine Department of Pharmacology |
| scientific contact | |
| Name | Naoki Matsumoto |
| Address | 2-16-1 Sugao, Miyamae-ward, Kawasaki, Kanagawa, Japan Japan |
| Telephone | 044-977-8111 |
| Affiliation | St. Marianna University School of Medicine Department of Pharmacology |