NIPH Clinical Trials Search

UMIN ID: UMIN000001027

Registered date:23/02/2008

The effects of collagen and hyaluronic acid for osteoarthritis symptoms study (CHAOS study), OCU-0704

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedOsteoarthritis of the knee
Date of first enrollment2008/02/01
Target sample size100
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)Period: 48 weeks Intervention group: the examination food (pigskin extraction collagen peptide 90.2%, hyaluronic acid 0.3%, mucopolysaccharides 0.8%, and water 8.7%) is taken, 5g a day. Control group: Hydrolysate of corn starch (maltodextrin) is taken. 5g a day


Primary OutcomeWOMAC score, joint narrowing of the knee (MTP view), SF-36, Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ)
Secondary OutcomeBone metabolic marker (BAP, NTx), cartilage metabolic marker (COMP)

Key inclusion & exclusion criteria

Age minimum45years-old
Age maximum80years-old
GenderMale and Female
Include criteria
Exclude criteriaartificial replacement of the knees, current use of NSAIDs, current use of steroid, rheumatoid arthritis patients, severe inflammation (ESR>=40mm/h or RF positive), intraarticular injection to the knees within 3 months, abnormal function of liver and kidney (2.5 times or more normal value), intake of alternative medicine (glcosamin, chondroitin sulfate, collagen, and hyaluronic acid) within 4 weeks, remarkable obesity (BMI>30), pregnant or nursing

Related Information


public contact
Name Hidekichi Tokai
Address Abenoku Asahimachi 1-2-7, Osaka, 545-8585, Japan Japan
Telephone 06-6645-3440
Affiliation Osaka City University Hospital Center for Drug & Food Clinical Evaluation
scientific contact
Name Tatsuya Koike
Address Abenoku Asahimachi 1-4-3, Osaka, 545-8585, Japan Japan
Telephone 06-6645-3984
Affiliation Osaka City University Medical School Department of Rheumatosurgery