Trial for in vitro screening of cytotoxic T lymphocyte induction with use of allogeneic dendritic cells for patients with pleural or peritoneal carcinomatosis

UMIN ID: UMIN000001016

Registered date:05/02/2008

Basic Information

• Recruitment status: Complete: follow-up continuing
• Health condition(s) or Problem(s) studied: Peritoneal or pleural carcinomatosis (carcinomas of the stomach, colorectum, biliary duct, pancreas, uterus, ovary, kidney, lung or malignant melanoma etc.) and malignant mesothelioma
• Date of first enrollment: 2008/02/01
• Target sample size: 100
• Countries of recruitment: Japan
• Study type: Observational

Outcome(s)

• Primary Outcome: Induction rate of cancer-specific cytotoxic T lymphocyte (CTL) in vitro
• Secondary Outcome: Cytotoxic potency or cytokine production of the cancer-specific CTL

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 80years-old
• Gender: Male and Female
• Exclude criteria: 1) Active double cancer. 2) Exclude the patients who have serious illness or suspect to have serious illness. 3) Myocardial infarction or unstable angina, occurred within 6 months. 4) Psychosis. 5) Women during pregnancy or breast-feeding. 6) Previous history of severe drug-induced allergy. 7) Exclude the patients who are recognized as inadequate patients by doctors with responsibility in this trial.

Related Information

• Primary Sponsor: Division of Gastrointestinal Surgery, Kobe University Hospital
• Source(s) of Monetary Support: None