Feasibility study of neoadjuvant chemotheray mFOLFOX6 for resectable liver metastases of colorectal cancers

UMIN ID: UMIN000000961

Registered date:07/01/2008

Basic Information

• Health condition(s) or Problem(s) studied: colorectal cancers
• Date of first enrollment: 2008/01/01
• Target sample size: 27
• Countries of recruitment: Japan
• Study type: Interventional
• Intervention(s): Surgery

Outcome(s)

• Primary Outcome: Curative resection rates of liver metastases

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 80years-old
• Gender: Male and Female
• Exclude criteria: Excluded are cases with conditions as below: 1) Peritoneal or pleural fluid retention to be drainaged. 2) Multiple malignancies to be treated. 3) Peripheral neural disturbances. 4) Active infectious diseases. 5) Severe watery diarrhea. 6) Mental disturbances. 7) Treatment history of continuous, oral or intravenous steroid therapy. 8) Previous history of ischemic heart diseases. 9) Coexistent severe diseases including pulmonary fibrosis, interstitial pneumonia, ileus, uncontrollable diabetes, cardiac dysfunction, hepatic failure, or renal failure. 10) Pregnant. 11) Previous history of severe drug-induced allergy.

Related Information

• Primary Sponsor: Dept. Surgey Kyoto University Hospital
• Source(s) of Monetary Support: Dept. Surgey Kyoto University Hospital