NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
UMIN ID: UMIN000000957

Registered date:27/12/2007

Clinical study of Landiolol hydrochloride in the treatment of postoperative atrial fibrillation/atrial flutter after cardiovascular surgery

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedtachyarrhythmia
Date of first enrollment2008/01/01
Target sample size400
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)Intravenous beta-blocker, Landiolol hydrochloride for up to 24 hrs Intravenous calcium channel blocker, Diltiazem hydrochloride for up to 24 hrs

Outcome(s)

Primary OutcomeAtrial fibrillation / atrial flutter (heart rate control, converting rate to normal sinus rhythm, palindromia rate)
Secondary OutcomeIschemic changes Changes of blood pressure Manifestation rate of bradycardia,atrioventricular block and cardiovascular events Length of ICU and hospitalization Cost of medical care after cardiovascular surgery Mortality rate in nosocomial

Key inclusion & exclusion criteria

Age minimum20years-old
Age maximum85years-old
GenderMale and Female
Include criteriaPatients after cardiovascular surgery *postoperative atrial fibrillation / atrial flutter with a ventricular rate more than or equal to 110 b.p.m. for a duration more than or equal to 5 min within 7 days after surgery
Exclude criteria(1) acute myocardial infarction within 3 days (2) supraventricular arrhythmia (3) sick sinus syndrome (containing patients with pacemaker) (4) grave heart failure (preoperative NYHA Classification of the Stages of Heart Failure, more than or equal to third degree) (5) atrioventricular block, more than or equal to second degree (6) contraindication to beta-blockers or , calcium channel blockers (7) electrolyte imbalance, WPW syndrome or hyperthyroidism (8) blood pressure < 90/60 mmHg (9) postoperative peroral use of beta-blockers or, calcium channel blockers (10) use of operative and postoperative antiarrhythmic medications excluding Digitalis

Related Information

Contact

public contact
Name Chol Kim
Address 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan Japan
Telephone 03-5814-6243
E-mail kim-nms@umin.net
Affiliation Nippon Medical School Department of Anesthesiolgy
scientific contact
Name Atsuhiro Sakamoto
Address 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan Japan
Telephone 03-5814-6243
E-mail
Affiliation Nippon Medical School Department of Anesthesiology