NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
UMIN ID: UMIN000000899

Registered date:19/11/2007

Improvement effects of pioglitazone on endothelial function after sirolimus-eluting stent (Cypher stent) implantation: a randomized, open rabelled, prospective study.

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedcoronary artery disease
Date of first enrollment2007/04/01
Target sample size50
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)Intervention group: Start to take pioglitazone 15mg per day after percutaneous coronary angioplasty and increase a dose to 30mg per day at 14days after angioplasty. And continue in 9 months. Control group: Take no pioglitazone in 9 months after percutaneous coronary angioplasty.

Outcome(s)

Primary OutcomeCoronary endothelial function with acetylcholine by quantitative coronary angiography. Plasma glucose, HbA1C, total cholesterol, triglyceride, LDL, HDL, MDA-LDL, HMW-adiponectin and hs-CRP. Major adverse cardiovascular event and harmful effect of pioglitazone.
Secondary OutcomePlasma GOT, GPT, T-BIL, ALP, LDH, CPK and BNP

Key inclusion & exclusion criteria

Age minimum20years-old
Age maximum85years-old
GenderMale and Female
Include criteria
Exclude criteriaAcute myocardial infarction, heart failure, severe hepatic or renal dysfunction, already to take pioglitazone, pregnancy and in-stent restenotic lesion.

Related Information

Contact

public contact
Name Hideki Kitahara
Address Japan
Telephone 043-222-7171
E-mail
Affiliation Chiba University Graduate School of Medicine Division of cardiovascular science and medicine
scientific contact
Name Issei Komuro
Address 1-8-1 Inohana, Chu-o ku, Chiba city, Chiba, JAPAN Japan
Telephone 043-222-7171
E-mail
Affiliation Chiba University Graduate School of Medicine Division of cardiovascular science and medicine