Treatment effects of antithrombin in septic patients with disseminated intravascular coagulation (DIC).

UMIN ID: UMIN000000882

Registered date:01/12/2007

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: Sepsis associated with disseminated intravascular coagulation (DIC).
• Date of first enrollment: 2008/01/01
• Target sample size: 200
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Antithrombin III, Three days, 30 IU/kg, One administration/day
No treatment.

Outcome(s)

• Primary Outcome: Improvement of DIC score, coagulation and fibrinolytic markers on the four days after antithrombin treatment.
• Secondary Outcome: Twenty-eight day mortality

Key inclusion & exclusion criteria

• Age minimum: 15years-old
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: 1) < Fifteen years of age, 2) Hematopoetic malignancy, 3) Comcomitant treatment with cartinostatics or irradiation, 4) Liver cirrhosis classified as Child-Pugh C, 5) Early phase of trauma and burn injury.

Related Information

• Primary Sponsor: Japanese Association for Acute Medicine
• Source(s) of Monetary Support: Japanese Association for Acute Medicine