UMIN ID: UMIN000000845
Registered date:07/10/2007
Intra-arterial injection of donor mesenchymal stromal cells for treating refractory acute Graft-vs-Host disease after hemopoietic stem cell transplantation
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | refractory acute GVHD |
| Date of first enrollment | 2006/04/01 |
| Target sample size | 8 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | Intra-arterial administration of donor-derived mesenchymal stromal cells |
Outcome(s)
| Primary Outcome | Clinical response at 2 weeks after MSC therapy |
|---|---|
| Secondary Outcome | Clinical response at 4 weeks after MSC therapy Overall survival at 4 weeks after MSC therapy |
Key inclusion & exclusion criteria
| Age minimum | 15years-old |
|---|---|
| Age maximum | Not applicable |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | 1.Positive for HIV Ab 2.Uncontrollable infection such as mucor, EBV-LPD, Gancyclovir-refractory CMV, measles. 3.severe psychiatric disorder |
Related Information
| Primary Sponsor | Department of Hematology, The Tazuke Kofukai Medical Research Institute Kitano Hospital |
|---|---|
| Secondary Sponsor | National Institute of Advanced Industrial Science and Technology, Research Institute for Cell Engineering |
| Source(s) of Monetary Support | CHUGAI PHARMACEUTICAL,Kirin Pharma Company, Limited |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Nobuyoshi Arima |
| Address | 2-4-20 Ohgimachi, Kita-ku, Osaka, JAPAN Japan |
| Telephone | |
| n-arima@kitano-ho.or.jp | |
| Affiliation | The Tazuke Kofukai Medical Research Institute Kitano Hospital Department of Hematology |
| scientific contact | |
| Name | Nobuyoshi Arima |
| Address | 2-4-20 Ohgimachi, Kita-ku, Osaka, JAPAN Japan |
| Telephone | |
| Affiliation | The Tazuke Kofukai Medical Research Institute Kitano Hospital Department of Hematology |