UMIN ID: UMIN000000845
Registered date:07/10/2007
Intra-arterial injection of donor mesenchymal stromal cells for treating refractory acute Graft-vs-Host disease after hemopoietic stem cell transplantation
Basic Information
Recruitment status | Complete: follow-up complete |
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Health condition(s) or Problem(s) studied | refractory acute GVHD |
Date of first enrollment | 2006/04/01 |
Target sample size | 8 |
Countries of recruitment | Japan |
Study type | Interventional |
Intervention(s) | Intra-arterial administration of donor-derived mesenchymal stromal cells |
Outcome(s)
Primary Outcome | Clinical response at 2 weeks after MSC therapy |
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Secondary Outcome | Clinical response at 4 weeks after MSC therapy Overall survival at 4 weeks after MSC therapy |
Key inclusion & exclusion criteria
Age minimum | 15years-old |
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Age maximum | Not applicable |
Gender | Male and Female |
Include criteria | |
Exclude criteria | 1.Positive for HIV Ab 2.Uncontrollable infection such as mucor, EBV-LPD, Gancyclovir-refractory CMV, measles. 3.severe psychiatric disorder |
Related Information
Primary Sponsor | Department of Hematology, The Tazuke Kofukai Medical Research Institute Kitano Hospital |
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Secondary Sponsor | National Institute of Advanced Industrial Science and Technology, Research Institute for Cell Engineering |
Source(s) of Monetary Support | CHUGAI PHARMACEUTICAL,Kirin Pharma Company, Limited |
Secondary ID(s) |
Contact
public contact | |
Name | Nobuyoshi Arima |
Address | 2-4-20 Ohgimachi, Kita-ku, Osaka, JAPAN Japan |
Telephone | |
n-arima@kitano-ho.or.jp | |
Affiliation | The Tazuke Kofukai Medical Research Institute Kitano Hospital Department of Hematology |
scientific contact | |
Name | Nobuyoshi Arima |
Address | 2-4-20 Ohgimachi, Kita-ku, Osaka, JAPAN Japan |
Telephone | |
Affiliation | The Tazuke Kofukai Medical Research Institute Kitano Hospital Department of Hematology |