Aichi - Research on Combination therapy in Hypertension (ARCH): Multi-center observational study on hypertensive's actual condition and effectiveness of the patient preference on an ARB and diuretic combination therapy in hypertensive patients who are under drug treatment

UMIN ID: UMIN000000816

Registered date:03/09/2007

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: Hypertension
• Date of first enrollment: 2007/09/01
• Target sample size: 1000
• Countries of recruitment: Japan
• Study type: Observational

Outcome(s)

• Primary Outcome: Systolic-blood-pressure change in three-month treatment.
• Secondary Outcome: 1.The rate of achieving the target SBP-DBP in three-month treatment 2.DBP change in the three-month treatment 3.The SBP/DBP changes and the rates of achieving the target blood pressure at 3,6, and 12 months 4.The rate of continued treatment and the compliance of the treatment 5.Rates of adverse experiences 6.Subanalysis on patient characteristics between the groups which achieves target blood pressure and which des not

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 75years-old
• Gender: Male and Female
• Exclude criteria: Exclusion criteria 1. Patients with the secondary hypertension 2. Patients with cardiac insufficiency (above NYHA grade III) 3.Women who are pregnant (positive urine pregnancy test at prestudy) or breast feeding, or expecting to conceive duration the study period 4. Patients with a critical liver damage 5. Patient with a history of severe hepatic or renal disease (sCr>2.0mg/dl) 6. Patients with a history of hypersensitivity to ingredients of Preminent. 7. Patients with a history of hypersensitivity to components of thiazide or similar compounds. 8. Patients who are considered to be not eligible to the study by the investigator due to medical reasons.

Related Information

• Primary Sponsor: Hypertension Academy in NAGOYA
• Source(s) of Monetary Support: Japan Heart foundation