UMIN ID: UMIN000000789
Registered date:10/08/2007
Antiremodeling effect of leukotriene receptor antagonist (pranlukast) in asthmatic subjects with chronic airflow limitation as assessed with computed tomography (CT).
Basic Information
| Recruitment status | Complete: follow-up continuing |
|---|---|
| Health condition(s) or Problem(s) studied | asthma |
| Date of first enrollment | 2005/06/01 |
| Target sample size | 30 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | Treatment with pranlukast 450 mg for 24 weeks |
Outcome(s)
| Primary Outcome | Bronchial wall thickness, mean lung density, % low attenuation area |
|---|---|
| Secondary Outcome | Pulmonary function tests Sputum eosinophil count Exhaled NO level Procollagen type 1 terminal peptide of sputum supernatant |
Key inclusion & exclusion criteria
| Age minimum | 20years-old |
|---|---|
| Age maximum | Not applicable |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | Subjects who suffered from respiratory tract infection in the previous month. Subjects who were taking NSAIDs. |
Related Information
| Primary Sponsor | Kyoto University Hospitaly |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Kyoto University Graduate School of Medicine |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Hirofumi Matsuoka |
| Address | 54 Kawahara, Shyogoin, Sakyo-ku, Kyoto Japan |
| Telephone | 075-751-3830 |
| Affiliation | Kyoto University Hospital Department of Respiratory Medicine |
| scientific contact | |
| Name | Akio Niimi |
| Address | 54 Kawahara, Shyogoin, Sakyo-ku, Kyoto Japan |
| Telephone | 075-751-3830 |
| Affiliation | Kyoto University Department of Respiratory Medicine |