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UMIN ID: UMIN000000749

Registered date:27/06/2007

Effect of physician-and pharmacist-cooperated intervention for lowering blood pressures among hypertensive patients.

Basic Information

Recruitment status	Complete: follow-up complete
Health condition(s) or Problem(s) studied	Essential hypertension
Date of first enrollment	2007/10/01
Target sample size	150
Countries of recruitment	Japan
Study type	Interventional
Intervention(s)	Standard medical care Intensive care (with pharmacist-led health promotion)

TO Original Data: UMIN

Outcome(s)

Primary Outcome	1) Blood pressure at clinic and home 2) Distribution of cessation or decrease of antihypertensive medications End point was variable change form baseline at 24 weeks.
Secondary Outcome	1) Urinary sodium and sodium reduction score 2) Regression of cardiovascular risk factors; obesity (waist circumference and BMI), prevalence of smoking, dyslipidemia, and prevalence of heavy alcohol drinking habit 3) Serum lipid: HDL cholesterol, LDL cholesterol, triglyceride 4) Liver function: gamma-GTP 5) Renal function: urinary microalbumin, creatinine, uric acid, and BUN 6) Glucose metabolism: HbAlc 7) Life style questionnaire score, SF-36 questionnaire score, and QOL score for antihypertensive medication 8) Costs and benefits of physician-and pharmacist-cooperated intervention

Primary Outcome

1) Blood pressure at clinic and home 2) Distribution of cessation or decrease of antihypertensive medications End point was variable change form baseline at 24 weeks.

Secondary Outcome

1) Urinary sodium and sodium reduction score 2) Regression of cardiovascular risk factors; obesity (waist circumference and BMI), prevalence of smoking, dyslipidemia, and prevalence of heavy alcohol drinking habit 3) Serum lipid: HDL cholesterol, LDL cholesterol, triglyceride 4) Liver function: gamma-GTP 5) Renal function: urinary microalbumin, creatinine, uric acid, and BUN 6) Glucose metabolism: HbAlc 7) Life style questionnaire score, SF-36 questionnaire score, and QOL score for antihypertensive medication 8) Costs and benefits of physician-and pharmacist-cooperated intervention

Key inclusion & exclusion criteria

Age minimum	40years-old
Age maximum	80years-old
Gender	Male and Female
Include criteria
Exclude criteria	- Secondary hypertension. - Severe renal failure or nephrotic syndrome. - Past history or under treatment of any cardiovascular disease. - Diabetes mellitus requiring medication. - Rheumatism or endocrine disease. - Exercise restriction over 20-min brisk walking or cycling per a day. - Other patients judged unsuitable for the study by physician.

Related Information

Primary Sponsor	Public Health, Department of Social and Environmental Medicine, Division of Preventive and Environmental Medicine, Graduate School of Medicine, Osaka University
Secondary Sponsor	Miho Medical Clinic, Horsemen's Benevolent Association, Japan Racing Association
Source(s) of Monetary Support	Public Health, Department of Social and Environmental Medicine, Division of Preventive and Environmental Medicine, Graduate School of Medicine, Osaka University,None
Secondary ID(s)

Contact

public contact
Name	Hiroko Tobari
Address	2-2 Yamadaoka, Suita-shi, Osaka, 565-0871, Japan Japan
Telephone	06-6879-3911
E-mail	h-tobari@umin.ac.jp
Affiliation	Osaka University, Graduate School of Medicine Public Health, Department of Social and Environmental Medicine
scientific contact
Name	Hiroyasu Iso
Address	2-2 Yamadaoka, Suita-shi, Osaka, 565-0871, Japan Japan
Telephone	06-6879-3911
E-mail
Affiliation	Osaka University, Graduate School of Medicine Public Health, Department of Social and Environmental Medicine, Division of Preventive and Environmental Medicine

TO Original Data: UMIN