UMIN ID: UMIN000000721
Registered date:31/03/2008
Effects of NSAIDS on activities of cartilage degrading enzymes in osteoarthritic knees
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | Osteoarthritis of the knee |
| Date of first enrollment | 2007/06/01 |
| Target sample size | 30 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | Diclofenac (COX-1 and 2 supressor) Meloxicam (selective COX-2 supressor) |
Outcome(s)
| Primary Outcome | MMP-3,9,13 and TIMP-1,2 of joint fluid |
|---|---|
| Secondary Outcome |
Key inclusion & exclusion criteria
| Age minimum | 55years-old |
|---|---|
| Age maximum | 75years-old |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | 1) Gastric ulcer 2) Liver disfunction 3) Uncontrolled hypertension 4) Allergy against aspirin 5) Asthma indeuced by aspirin 6) Pregnancy 7) Other condtitions that are not suitable for the study judged by medical doctors |
Related Information
| Primary Sponsor | Department of orthopaedic surgery, Graduate school of medicine, Chiba University |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Department of orthopaedic surgery, Graduate school of medicine, Chiba University |
| Secondary ID(s) |
Contact
| public contact | |
| Name | |
| Address | Japan |
| Telephone | |
| shiken@office.chiba-u.jp | |
| Affiliation | Graduate school of medicine, Chiba University Department of orthopaedic surgery |
| scientific contact | |
| Name | TAKAHISA SASHO |
| Address | 1-8-1, Inohana, Cyuou, Chiba Japan |
| Telephone | 043-226-2117 |
| Affiliation | Graduate school of medicine, Chiba University Department of orthopaedic surgery |