NIPH Clinical Trials Search

UMIN ID: UMIN000000697

Registered date:02/05/2007

Japan colorectal tumor prevention study: randomized controlled trial by low-dose aspirin

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedcolorectal tumor
Date of first enrollment2007/01/01
Target sample size700
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)Aspirin (100 mg/day) enteric-coated tablet Placebo tablet / day


Primary OutcomeOnly the occurrence of a colorectal tumor (adenoma or cancer) is selected as the primary endpoint.
Secondary Outcome

Key inclusion & exclusion criteria

Age minimum40years-old
Age maximum70years-old
GenderMale and Female
Include criteria
Exclude criteria# Patients with a medical history of submucosal or deeper colorectal cancer. # Patients currently taking antithrombotics such as Bayaspirin, Bufferin, Panaldine, Warfarin and Persantin. # Patients who have undergone colorectal resection (those who have undergone appendectomy are allowed to participate in the study). # Patients with familial colorectal adenoma. # Patients with a history of treatment of gastric or duodenal ulcer (those with successful eradication of Helicobacter pylori and ulcer resolution at S2 are allowed to participate in the study) # Patients with bleeding tendency, a platelet count of 150,000, or with abnormal PT # Patients with any existing cancer at the time of participation in the study. # Patients with known allergy to aspirin. # Patients currently taking anticancer drugs. # Women who are or may be pregnant during the study period. # Patients currently taking NSAIDs at least 3 times weekly, for example, as a analgesic.

Related Information


public contact
Name Hideki Ishikawa
Address 3-1-2F Kyomachibori Nishi-ku 2-chome Osaka 550-0003, Japan Japan 541-0042
Telephone 06-6445-5585
Affiliation Kyoto Prefectural University of Medicine Department of Molecular-Targeting Cancer Prevention
scientific contact
Name Sadao Suzuki
Address Mizuho-ku, Nagoya 467-8601 Japan
Telephone 052-853-8174
Affiliation Nagoya City University Medical School Department of Health Promotion and Preventive Medicine