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UMIN ID: UMIN000000667

Registered date:01/11/2008

Effects of renal dysfunction and sleep apnea on ambulatory blood pressure profile, cardiovascular function, and glucose and lipid metabolism: cross-sectional and prognosis study.

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedHypertensionj
Date of first enrollment2005/04/01
Target sample size500
Countries of recruitmentJapan
Study typeObservational


Primary Outcome1) casual blood pressure 2) ambulatory blood pressure monitoring 3) sleep apnea test 4) renal function: creatinine clearance by Cockcroft-Gault formula 5) glucose metabolism: fasting blood glucose, fasting IRI, HOMA-IR 6) lipid metabolism: total cholesterol, LDL, HDL, TG, adiponectin 7) cardiac function: ANP, BNP, UCG 8) vascular function: ABI/BWV, carotid echogram 9) sympathetic nerve activity and renin-angiotensin system 10) inflammatory and oxidative markers: CRP, fibrinogen, MDA-LDL, AGE.
Secondary Outcome

Key inclusion & exclusion criteria

Age minimum20years-old
Age maximumNot applicable
GenderMale and Female
Include criteria
Exclude criteriaacute myocardial infarction, collagen disease, acute renal failure

Related Information


public contact
Name Kazukai Uchino
Address 3-9 Fukuura, Kanazawa-ku Japan
Telephone 045-787-2634
Affiliation Yokohama City University School of Medicine Department of Medical Science
scientific contact
Name Kouichi TAMURA
Address 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JAPAN Japan
Telephone 045-787-2635
Affiliation Yokohama City University School of Medicine Department of Cardiorenal Medicine